Description

N1,N1-Dimethyl-N3-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Propane-1,3-Diamine is a high-purity, advanced pharmaceutical intermediate featuring a pyridine core and a protected boronic ester functional group. This compound is of significant value for its role as a key building block in modern medicinal chemistry, particularly in the synthesis of complex molecules via cross-coupling reactions. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), especially within oncology and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly for targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronic ester group makes it an essential reagent for constructing biaryl and heterobiaryl structures, a cornerstone of modern drug discovery.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities.
• Ligand Synthesis: The diamine moiety can be utilized to develop novel ligands for catalysis or metal-organic frameworks.
• Chemical Biology Probes: Serves as a building block for creating molecular probes to study biological pathways and target engagement.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing.

Basic Information

Product Name	N1,N1-Dimethyl-N3-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Propane-1,3-Diamine
CAS No.	1353718-66-7
Molecular Formula	C19H34BN3O2
Molecular Weight	347.31 g/mol
Synonyms	2-[[3-(Dimethylamino)propyl]amino]-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[[3-(dimethylamino)propyl]amino]-4-methylpyridine; N3-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-2-pyridinyl]-N1,N1-dimethyl-1,3-propanediamine; 1,3-Propanediamine, N1,N1-dimethyl-N3-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-2-pyridinyl]-
EINECS	Contact for details

Quality Control

Our N1,N1-Dimethyl-N3-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Propane-1,3-Diamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.