Description

o-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Hydroxylamine is a high-value, functionalized pyridine boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in the unique combination of a protected hydroxylamine group and a stable pinacol boronate ester, enabling precise and efficient construction of complex nitrogen-containing heterocycles. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients through advanced cross-coupling and functionalization strategies.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, especially those containing pyridine and hydroxylamine pharmacophores.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester moiety acts as a versatile handle for palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific heterocyclic architectures.
• Material Science Research: Intermediate for creating functional organic molecules and ligands used in catalysis and advanced materials.
• Chemical Biology & Proteomics: Potential use in the synthesis of probes and linkers for studying biological systems and protein interactions.
• Academic & R&D Laboratories: A valuable reagent for methodological development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	o-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Hydroxylamine
CAS No.	1353718-44-1
Molecular Formula	C12H19BN2O3
Molecular Weight	250.11 g/mol
Synonyms	2-((4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)oxy)amine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methylpyridin-2-yl-hydroxylamine; 2-Aminooxy-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; O-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-2-pyridinyl]hydroxylamine; 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine N-oxide (tautomer); Pinacol [2-(Aminooxy)-4-methyl-5-pyridinyl]boronate
EINECS	Contact for details

Quality Control

Our o-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Hydroxylamine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0 %
Residue on Ignition	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.