Description

n-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Hydroxylamine is a high-value, functionalized pyridine derivative containing both a hydroxylamine and a pinacol boronate ester group. This unique bifunctional structure makes it a critical advanced pharmaceutical intermediate (API) and a versatile building block for modern synthetic chemistry. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules via cross-coupling and functional group manipulation.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic development.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester moiety serves as a crucial handle for forming carbon-carbon bonds with aryl/heteroaryl halides, enabling rapid scaffold diversification.
• Functional Group Transformation: The hydroxylamine group can be utilized for the introduction of N-O containing functionalities or further reduced to amines, adding synthetic flexibility.
• Agrochemical Synthesis: Building block for creating new active ingredients with potential herbicidal or insecticidal properties.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for catalysis or metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful in the design of molecular probes for studying biological pathways and protein interactions.

Basic Information

Product Name	n-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Hydroxylamine
CAS No.	1353718-43-0
Molecular Formula	C12H19BN2O3
Molecular Weight	250.11 g/mol
Synonyms	2-(N-Hydroxyamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methylpyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methylpyridin-2-amine N-oxide; N-Hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methylpyridin-2-amine; 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl-hydroxylamine; PINACOL [5-(HYDROXYAMINO)-4-METHYLPYRIDIN-2-YL]BORONATE; 1353718-43-0; BCP26123; ZB0147
EINECS	Contact for details

Quality Control

Every batch of n-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Hydroxylamine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.