Description

1-Chloro-4-Methoxy-8,9-Dihydro-5H-Benzo[7]Annulen-7(6H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused benzannulene structure. This compound is critical for the synthesis of complex organic molecules, offering a versatile halogenated and methoxylated scaffold for targeted chemical modifications. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. The compound, CAS 1352925-25-7, is supplied under stringent quality control to ensure batch-to-batch consistency for demanding synthetic applications.

Application

This specialized intermediate serves as a key building block in sophisticated organic synthesis. Its primary applications include:

• Pharmaceutical Research & Development: As a core scaffold for the synthesis of novel drug candidates targeting various therapeutic areas.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex APIs, leveraging its reactive chloro and ketone functional groups.
• Chemical Biology & Medicinal Chemistry: Employed in the design and construction of molecular probes and libraries for structure-activity relationship (SAR) studies.
• Fine Chemical Production: Serves as a precursor for the manufacture of other high-value, specialty chemicals and advanced intermediates.
• Academic & Industrial Research: Utilized in methodological development and exploratory synthesis of novel heterocyclic and polycyclic compounds.

Basic Information

Product Name	1-Chloro-4-Methoxy-8,9-Dihydro-5H-Benzo[7]Annulen-7(6H)-One
CAS No.	1352925-25-7
Molecular Formula	C13H13ClO2
Molecular Weight	236.69 g/mol
Synonyms	1-Chloro-4-methoxy-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one; 7(6H)-Benzocycloheptenone, 1-chloro-4-methoxy-8,9-dihydro-5H-; 1-Chloro-4-methoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-7-one; 5H-Benzo[7]annulen-7(6H)-one, 1-chloro-4-methoxy-8,9-dihydro-; 1352925-25-7
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-Methoxy-8,9-Dihydro-5H-Benzo[7]Annulen-7(6H)-One is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity, purity, and conformity to established specifications. Certificates of Analysis (COA) documenting all critical quality attributes are provided and available upon request, ensuring full traceability and compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.