Description

4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3H-1,3-Benzodiazole is a high-value boronic ester derivative of benzimidazole, serving as a critical building block in modern synthetic chemistry. Its primary value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, where it is used to develop novel active ingredients and advanced functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing benzimidazole and biaryl motifs for oncology, antiviral, and CNS drugs.
• Agrochemical Synthesis: Used to create novel fungicides, herbicides, and insecticides with enhanced efficacy and selectivity.
• Materials Science Research: Building block for organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and other electronic materials requiring precise molecular architecture.
• Ligand and Catalyst Development: Serves as a precursor for N-heterocyclic carbene (NHC) ligands and other organometallic catalysts.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for studying biological processes.
• Polymer Chemistry: Monomer for constructing specialty polymers with tailored thermal, optical, or mechanical properties.

Basic Information

Item	Details
Product Name	4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3H-1,3-Benzodiazole
CAS No.	1352796-63-4
Molecular Formula	C₁₃H₁₇BN₂O₂
Molecular Weight	244.10 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole; 1H-Benzimidazole, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole; Benzimidazole-4-boronic acid pinacol ester; 4-Borono-1H-benzimidazole pinacol ester; 4-(Benzimidazolyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3H-1,3-Benzodiazole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.