Description

n-(3-Methoxypropyl)-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is a high-value, functionalized pyridine boronic ester derivative, serving as a critical advanced pharmaceutical intermediate and building block in modern synthetic chemistry. Its core value lies in enabling the Suzuki-Miyaura cross-coupling reaction, a pivotal method for constructing complex carbon-carbon bonds under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require precise and efficient synthesis of novel molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific pyridine-based scaffolds.
• Material Science Research: Serves as a monomer or functional unit in the creation of organic electronic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and bioconjugation reagents for target identification and labeling studies.
• Catalyst Ligand Precursor: Can be utilized to synthesize novel ligand systems for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	n-(3-Methoxypropyl)-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine
CAS No.	1352741-90-2
Molecular Formula	C16H27BN2O3
Molecular Weight	306.21 g/mol
Synonyms	4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(3-methoxypropyl)pyridin-2-amine; 2-Amino-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine N-(3-methoxypropyl) derivative; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-N-(3-methoxypropyl)pyridin-2-amine; Boronic ester, B-(6-[(3-methoxypropyl)amino]-4-methyl-3-pyridinyl)-, 1,3,2-dioxaborolane deriv.; CAS 1352741-90-2; Pyridineboronic acid pinacol ester derivative
EINECS	Contact for details

Quality Control

Every batch of our n-(3-Methoxypropyl)-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, meeting the stringent requirements of research and cGMP manufacturing environments. Our quality assurance protocols include HPLC, NMR, and MS analysis to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.