Description

6-Trifluoromethoxypyridine-3-Boronic Acid Pinacol Ester is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound matters for its role as a key intermediate in the Suzuki-Miyaura cross-coupling reaction, enabling the efficient construction of complex biaryl and heterobiaryl structures. Pharmaceutical, agrochemical, and advanced materials researchers need it for developing novel active ingredients and functional molecules, where the trifluoromethoxy group imparts unique metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: Critical for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the trifluoromethoxy moiety for enhanced biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for creating advanced organic electronic materials, such as ligands for OLEDs, OFETs, and conductive polymers.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological processes and enzyme functions.
• Cross-Coupling Reactions: A specialized reagent for Suzuki-Miyaura cross-coupling to introduce the 3-pyridyl boronate moiety into complex molecular architectures under mild conditions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research laboratories for custom synthesis projects requiring high-fidelity boronic ester couplings.

Basic Information

Item	Detail
Product Name	6-Trifluoromethoxypyridine-3-Boronic Acid Pinacol Ester
CAS No.	1352741-13-9
Molecular Formula	C₁₃H₁₅BF₃NO₃
Molecular Weight	301.07 g/mol
Synonyms	6-(Trifluoromethoxy)pyridine-3-boronic acid pinacol ester; 3-Pyridineboronic acid, 6-(trifluoromethoxy)-, 1,1-dimethylethyl ester; 6-Trifluoromethoxy-3-pyridylboronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethoxy)pyridine; 2-(Trifluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 6-Trifluoromethoxypyridin-3-ylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 6-Trifluoromethoxypyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and GC/MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP and ISO 9001 principles for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.