Description

(2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanol is a high-value organoboron building block, specifically a boronic ester derivative with a benzylic alcohol functional group. This compound is critical for modern synthetic chemistry, enabling the precise construction of complex molecules through cross-coupling reactions. It is primarily utilized by pharmaceutical, agrochemical, and advanced materials research and development teams for the synthesis of novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing fluorinated biaryl compounds, which are prevalent motifs in drug discovery for metabolic stability and bioavailability enhancement.
• Agrochemical Synthesis: Used to create novel, fluorinated active ingredients for crop protection agents, leveraging the unique properties of the fluorine atom and the boronic ester handle.
• Liquid Crystal & OLED Material Development: Serves as a building block for creating fluorinated aromatic cores in advanced electronic and display materials, where precise molecular architecture is essential.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and functionalized materials, where the boronic ester group allows for further modular functionalization.
• Chemical Biology & Probe Development: Utilized in the creation of molecular probes and tags for studying biological systems, benefiting from the orthogonal reactivity of the boronate and alcohol groups.

Basic Information

Product Name	(2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanol
CAS No.	1352733-99-3
Molecular Formula	C13H18BFO3
Molecular Weight	252.09 g/mol
Synonyms	2-Fluoro-5-(hydroxymethyl)phenylboronic acid pinacol ester; (5-(Hydroxymethyl)-2-fluorophenyl)boronic acid pinacol ester; 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenemethanol; 2-Fluoro-5-(pinacolatoboryl)benzyl alcohol; 5-(Hydroxymethyl)-2-fluorobenzeneboronic acid pinacol ester; Benzenemethanol, 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our (2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.