Description

2-(Dimethylamino)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isonicotinaldehyde is a high-value, multi-functional boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a protected boronic acid group and an aldehyde functionality, makes it an indispensable reagent for constructing complex molecular architectures via cross-coupling and subsequent functionalization. This compound is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and oncology research.
• Agrochemical Synthesis: Used to construct complex heterocyclic scaffolds found in next-generation herbicides, fungicides, and insecticides.
• Material Science Research: Building block for creating organic electronic materials, such as ligands for OLEDs and charge-transport molecules.
• Chemical Biology Probes: Enables the synthesis of tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Essential for CROs and CDMOs offering bespoke chemical synthesis services to clients.
• Academic Research: Used in university and institutional labs for methodological development in organoboron chemistry and catalysis.

Basic Information

Product Name	2-(Dimethylamino)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isonicotinaldehyde
CAS No.	1352730-09-6
Molecular Formula	C16H23BN2O3
Molecular Weight	302.18 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(dimethylamino)isonicotinaldehyde; 2-(Dimethylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-4-carboxaldehyde; 2-Dimethylamino-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-isonicotinaldehyde; 1352730-09-6; PINACOL (2-(DIMETHYLAMINO)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISONICOTINALDEHYDE); 2-(Dimethylamino)-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)isonicotinaldehyde
EINECS	Contact for details

Quality Control

Every batch of 2-(Dimethylamino)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isonicotinaldehyde is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, NMR, and MS analysis, to ensure high purity and batch-to-batch consistency suitable for demanding research and scale-up applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and easily oxidized nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.