Description

2-(Cyclohexyloxy)Thiazole-5-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile organoboron building block. This compound is critical for facilitating efficient carbon-carbon bond formation in complex molecule synthesis, particularly in medicinal chemistry. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel thiazole-containing scaffolds.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for introducing the functionalized thiazole moiety into complex molecules, enabling the synthesis of potential drug candidates and advanced materials.
• Pharmaceutical Intermediate: Serves as a critical building block in the research and development of new active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that incorporate the thiazole heterocycle for enhanced biological activity.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as OLEDs and semiconductors, where the thiazole unit can modify electronic properties.
• Chemical Biology & Probe Development: Utilized for creating molecular probes and labeled compounds for biochemical assays and diagnostic research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring this specialized boronic ester.

Basic Information

Product Name	2-(Cyclohexyloxy)Thiazole-5-Boronic Acid Pinacol Ester
CAS No.	1352652-25-5
Molecular Formula	C15H24BNO3S
Molecular Weight	309.23 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(cyclohexyloxy)thiazole; 2-Cyclohexyloxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; 2-(Cyclohexyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; Thiazole-5-boronic acid, 2-(cyclohexyloxy)-, pinacol ester; 2-(Cyclohexyloxy)thiazol-5-ylboronic acid pinacol ester; Boronic acid, B-[2-(cyclohexyloxy)-5-thiazolyl]-, 1,1,1',1'-tetramethyl-4,4'-bi-1,3,2-dioxaborolane-2,2'-diyl ester
EINECS	Contact for details

Quality Control

Our 2-(Cyclohexyloxy)Thiazole-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and easily oxidized nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.