Description

1-(6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Pyrrolidin-2-One is a high-purity, advanced pharmaceutical intermediate featuring a pyridine core functionalized with a pinacol boronate ester and a pyrrolidinone moiety. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex, drug-like molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, particularly in oncology and CNS disorders.

Application

• Suzuki-Miyaura Cross-Coupling Reagent: A key boron-containing reagent for constructing biaryl and heterobiaryl linkages in small molecule drug candidates.
• Pharmaceutical Intermediate: Serves as a versatile synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs) and preclinical candidates.
• Medicinal Chemistry Research: Used in library synthesis for structure-activity relationship (SAR) studies and hit-to-lead optimization programs.
• Ligand Synthesis: A precursor for creating novel ligands and catalysts used in asymmetric synthesis and other catalytic processes.
• Agrochemical Development: Employed in the research and synthesis of novel agrochemicals and plant protection agents.
• Material Science: Potential building block for organic electronic materials and functional polymers.

Basic Information

Product Name	1-(6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Pyrrolidin-2-One
CAS No.	1352645-48-7
Molecular Formula	C15H21BN2O3
Molecular Weight	288.15 g/mol
Synonyms	1-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]pyrrolidin-2-one; 2-(2-Oxopyrrolidin-1-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2-oxopyrrolidin-1-yl)pyridine; 1-(6-(Pinacolboryl)pyridin-2-yl)pyrrolidin-2-one; 2-(2-Oxo-1-pyrrolidinyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
EINECS	Contact for details

Quality Control

Our 1-(6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Pyrrolidin-2-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each lot, supporting compliance with research and development standards. We are committed to supplying material that meets the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and moisture absorption. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.