Description

5-Chloro-2-Methylphenylboronic Acid, Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in medicinal chemistry programs targeting CNS and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, contributing to the creation of compounds with enhanced efficacy and environmental profiles.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics (OPVs).
• Chemical Biology & Probe Development: Acts as a versatile handle for bioconjugation and the creation of molecular probes for studying biological processes and target engagement.
• Catalyst & Ligand Preparation: Serves as a starting material for the synthesis of specialized ligands and catalysts used in asymmetric synthesis and other catalytic transformations.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical manufacturers for the production of bespoke compounds and advanced intermediates under cGMP or ISO standards.

Basic Information

Product Name	5-Chloro-2-Methylphenylboronic Acid, Pinacol Ester
CAS No.	1352426-91-5
Molecular Formula	C13H18BClO2
Molecular Weight	252.54 g/mol
Synonyms	5-Chloro-2-methylbenzeneboronic acid pinacol ester; (5-Chloro-2-methylphenyl)boronic acid pinacol ester; 2-Methyl-5-chlorophenylboronic acid pinacol ester; B-(5-Chloro-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Chloro-o-tolylboronic acid pinacol ester; CAS 1352426-91-5; Pinacol (5-chloro-2-methylphenyl)boronate
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Methylphenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistent performance in sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.