Description

tert-Butyl 3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidine-1-Carboxylate is a high-value, protected piperidine boronic ester building block essential for modern synthetic chemistry. This compound matters because it provides a versatile handle for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. Pharmaceutical, agrochemical, and advanced materials researchers need this intermediate for the discovery and development of new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging the boronic ester group for structural diversification.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs or organic semiconductors.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a coupling partner with aryl/heteroaryl halides to form biaryl and heterobiaryl linkages under palladium catalysis.
• Parallel and Combinatorial Chemistry: Ideal for library synthesis due to its stability and reactivity, allowing for the rapid generation of diverse compound sets for screening.
• Peptidomimetic and Scaffold Development: The piperidine core is a privileged structure in drug design, used to create conformationally constrained analogs and novel scaffolds.

Basic Information

Product Name	tert-Butyl 3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidine-1-Carboxylate
CAS No.	1352426-78-8
Molecular Formula	C22H34BNO4
Molecular Weight	387.32 g/mol
Synonyms	1-Boc-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine; 3-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidine-1-carboxylate; 1,1-Dimethylethyl 3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-piperidinecarboxylate; 3-(3-BPin-phenyl)piperidine-1-carboxylic acid tert-butyl ester; N-Boc-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidine-1-Carboxylate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development. All batches are fully characterized by NMR, HPLC, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with internal quality standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent hydrolysis of the boronic ester group.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.