Description

n-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Benzenesulfonamide is a high-purity, advanced pharmaceutical intermediate featuring a key boronic ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex drug candidates. It is primarily needed by R&D and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel small-molecule therapeutics.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester reagent for constructing biaryl and heterobiaryl structures central to many active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors, antiviral agents, and other therapeutic compounds.
• Agrochemical Research: Used in the development of new herbicides and fungicides that require specific aryl-aryl linkages.
• Material Science: Potential building block for organic electronic materials and metal-organic frameworks (MOFs) due to its conjugated system and boronate functionality.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed in the synthesis of bifunctional molecules for targeted protein degradation research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and libraries for high-throughput screening.

Basic Information

Product Name	n-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Benzenesulfonamide
CAS No.	1352414-70-0
Molecular Formula	C18H23BN2O4S
Molecular Weight	374.26 g/mol
Synonyms	Benzenesulfonamide, N-[4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methylpyridin-2-amine benzenesulfonamide; 2-(4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylamino)benzenesulfonamide (isomer); 1352414-70-0; Pinacol ester of [5-(Phenylsulfonamido)-4-methylpyridin-2-yl]boronic acid; N-(4-Methyl-5-(pinacolatoboryl)pyridin-2-yl)benzenesulfonamide
EINECS	Contact for details

Quality Control

Our n-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Benzenesulfonamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting standards for pharmaceutical intermediates. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.