Description

n-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Morpholin-4-Amine CAS NO 1352414-69-7 is a high-value, advanced pharmaceutical intermediate belonging to the class of pyridine-based boronic acid pinacol esters. This compound is critical for enabling efficient cross-coupling reactions, particularly in the synthesis of complex small molecule APIs. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing active pharmaceutical ingredients (APIs).
• Drug Discovery Research: Used in medicinal chemistry for the rapid parallel synthesis and library generation of drug candidates targeting various diseases.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and probes for studying biological pathways and target engagement.
• Process Chemistry: Serves as a reliable and stable boronate reagent for scalable manufacturing processes under GMP conditions.

Basic Information

Product Name	n-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Morpholin-4-Amine
CAS No.	1352414-69-7
Molecular Formula	C16H26BN3O3
Molecular Weight	319.21 g/mol
Synonyms	4-Morpholin-N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-2-pyridinyl]amine; 2-Morpholino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-picoline; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-2-(morpholin-4-ylamino)pyridine; 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl-morpholin-4-amine; N-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methylpyridin-2-yl)morpholin-4-amine; Boronic ester pyridine intermediate 1352414-69-7.
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Quality Control

Our production of n-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Morpholin-4-Amine adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. All material is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We implement rigorous analytical controls including HPLC, NMR, and LC-MS to meet the exacting standards required for pharmaceutical R&D and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) in a desiccated environment to maintain stability and purity. Avoid prolonged exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.