Description

4-Methyl-2-(4-Methyl-1H-Pyrazol-1-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value, multi-functional heterocyclic building block containing a pyridine core, a pyrazole substituent, and a boronic ester pinacol protecting group. This compound matters as a critical intermediate in modern pharmaceutical and agrochemical research, enabling efficient cross-coupling reactions like the Suzuki-Miyaura reaction for constructing complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its boronic ester functionality for structural diversification.
• Material Science Research: Serves as a precursor for creating organic electronic materials, ligands for catalysts, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling: The protected boronic ester group makes it an ideal, stable reagent for palladium-catalyzed carbon-carbon bond formation under mild conditions.
• Chemical Biology & Probe Development: Utilized in creating molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	4-Methyl-2-(4-Methyl-1H-Pyrazol-1-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1352414-67-5
Molecular Formula	C16H22BN3O2
Molecular Weight	299.18 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(4-methyl-1H-pyrazol-1-yl)-4-picoline; 2-(4-Methyl-1H-pyrazol-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methylpyridine; 4-Methyl-2-(4-methylpyrazol-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 1-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methylpyridin-2-yl)-4-methyl-1H-pyrazole; Boric acid, cyclic ester with 2-(4-methyl-1H-pyrazol-1-yl)-4-methyl-5-pyridineboronic acid
EINECS	Contact for details

Quality Control

Our 4-Methyl-2-(4-Methyl-1H-Pyrazol-1-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive cross-coupling applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.