Description

Thiomorpholine, 4-[4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Pyridinyl]-, 1,1-Dioxide is a high-value, advanced pharmaceutical intermediate featuring a pyridine core functionalized with a pinacol boronate ester and a sulfonated thiomorpholine group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient Suzuki-Miyaura cross-coupling reactions for the synthesis of complex, bioactive molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel drug candidates and active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) via palladium-catalyzed cross-coupling.
• Medicinal Chemistry R&D: Enables the rapid exploration of structure-activity relationships (SAR) in drug discovery programs, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides requiring complex heterocyclic architectures.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands or functional materials in catalysis research.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	Thiomorpholine, 4-[4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Pyridinyl]-, 1,1-Dioxide
CAS No.	1352414-64-2
Molecular Formula	C16H25BN2O4S
Molecular Weight	352.26 g/mol
Synonyms	4-(4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)thiomorpholine 1,1-dioxide; 2-(1,1-Dioxido-4-thiomorpholinyl)-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(thiomorpholine-1,1-dioxide-4-yl)pyridine; Pinacol ester of [4-Methyl-5-(1,1-dioxidothiomorpholin-4-yl)pyridin-2-yl]boronic acid; Boronic acid pinacol ester intermediate; Suzuki-Miyaura coupling reagent; Pharmaceutical Boronate Ester.
EINECS	Contact for details

Quality Control

Our Thiomorpholine, 4-[4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Pyridinyl]-, 1,1-Dioxide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive coupling reactions. All products undergo rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to confirm identity, purity, and the absence of critical impurities like palladium catalysts. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening the container for use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.