Description

(4-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperazin-1-Yl)Methanol is a sophisticated boronic ester-protected heterocyclic building block designed for advanced organic synthesis. This compound matters because it provides a stable, reactive handle for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. Pharmaceutical researchers and fine chemical manufacturers need this high-purity intermediate for the efficient development of novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boron-containing coupling partner for forming carbon-carbon bonds between aromatic and heteroaromatic systems.
• Medicinal Chemistry Research: Enables the rapid exploration of structure-activity relationships (SAR) by introducing the piperazine-methanol substituted pyridine scaffold into target molecules.
• Ligand and Catalyst Development: Used in the preparation of novel chelating ligands or organocatalysts due to its nitrogen-rich, functionalized structure.
• Agrochemical Synthesis: Employed in the research and development of new, high-performance crop protection agents.
• Material Science Precursor: Acts as a monomer or functionalizing agent in the creation of advanced polymers and organic electronic materials.

Basic Information

Product Name	(4-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperazin-1-Yl)Methanol
CAS No.	1352414-63-1
Molecular Formula	C20H32BN3O3
Molecular Weight	373.30 g/mol
Synonyms	2-Piperazin-1-yl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-picolinemethanol; 4-(4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazin-1-ylmethanol; (4-(4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazin-1-yl)methanol; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(piperazin-1-yl)isonicotinyl alcohol; PINAP Boronate Ester Derivative; Boro-Piperazine Pyridine Methanol
EINECS	Contact for details

Quality Control

Our (4-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperazin-1-Yl)Methanol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and production use. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.