Description

3-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Ylamino)Propan-1-Ol is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Suzuki-Miyaura Cross-Coupling: Serves as a crucial boron-containing coupling partner for constructing biaryl and heterobiaryl structures central to many modern pharmaceuticals.
• Medicinal Chemistry Research: Enables rapid prototyping and structure-activity relationship (SAR) studies in early-stage drug discovery programs.
• API Development: Used in the process research and scale-up stages for developing new active pharmaceutical ingredients.
• Ligand Synthesis: Can be utilized in the preparation of novel ligands for catalysis or metal-organic frameworks (MOFs).
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with complex heterocyclic structures.

Basic Information

Product Name	3-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Ylamino)Propan-1-Ol
CAS No.	1352414-61-9
Molecular Formula	C15H25BN2O3
Molecular Weight	292.19 g/mol
Synonyms	2-[(3-Hydroxypropyl)amino]-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 1-Propanol, 3-[[4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]amino]-; 3-((4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)amino)propan-1-ol; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[(3-hydroxypropyl)amino]-4-methylpyridine; CAS 1352414-61-9
EINECS	Contact for details

Quality Control

Our 3-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Ylamino)Propan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP standards where applicable to support our clients' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) when opened for use to prevent degradation. For long-term storage, consider storing under an inert gas blanket in the original sealed container.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.