Description

Methyl 2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Nitrophenyl)Acetate is a high-value, multi-functional chemical intermediate featuring both a boronic ester pinacol group and a nitro-substituted aromatic ring. This compound is essential for facilitating advanced cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern pharmaceutical and agrochemical synthesis. It is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for constructing biaryl structures via palladium-catalyzed cross-coupling.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific aromatic boronate components.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and bioconjugation reagents that utilize the boronate functionality for selective binding or labeling.
• Academic & Industrial R&D: A versatile reagent for methodological development in organic synthesis and catalysis studies within university and corporate laboratories.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	Methyl 2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Nitrophenyl)Acetate
CAS No.	1352413-08-1
Molecular Formula	C15H20BNO6
Molecular Weight	321.14 g/mol
Synonyms	2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-nitrophenyl)acetic acid methyl ester; Methyl (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-nitrophenyl)acetate; 2-Nitro-4-(pinacolboryl)phenylacetic acid methyl ester; 4-(Pinacolboron)-2-nitrophenylacetic acid methyl ester; Methyl 2-(2-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate; (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-nitrophenyl)acetic acid methyl ester; PINACOL (4-(METHOXYCARBONYLMETHYL)-3-NITROPHENYL)BORONATE
EINECS	Contact for details

Quality Control

Our Methyl 2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Nitrophenyl)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.