Description

N,n-Diethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazol-2-Amine is a high-value organoboron building block, specifically a pinacol boronate ester derivative of a substituted thiazole. This compound matters as a critical intermediate in modern synthetic chemistry, enabling precise carbon-carbon bond formation via cross-coupling reactions like the Suzuki-Miyaura reaction. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing thiazole heterocycles.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a precursor for creating functional organic materials, including organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: Primarily utilized in Suzuki-Miyaura coupling to introduce the 5-substituted thiazol-2-amine moiety into more complex molecules.
• Chemical Biology & Medicinal Chemistry: Enables the synthesis of molecular probes and tool compounds for target identification and validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects.

Basic Information

Product Name	N,n-Diethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazol-2-Amine
CAS No.	1352334-85-0
Molecular Formula	C15H27BN2O2S
Molecular Weight	310.26 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N,N-diethylthiazol-2-amine; 2-Amino-N,N-diethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; N,N-Diethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-thiazolamine; 1352334-85-0; Thiazole boronic acid pinacol ester derivative; Boronate ester thiazole intermediate
EINECS	Contact for details

Quality Control

Our N,n-Diethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazol-2-Amine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity and impurity profiles are provided with every shipment to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.