Description

1,3-Dihydroisobenzofuran-5-Boronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and fine chemical synthesis.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl/heteroaryl halides and this boronic ester, fundamental in medicinal chemistry.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those containing the dihydroisobenzofuran scaffold.
• Agrochemical Product Development: Employed in creating novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science & OLED Development: Acts as a precursor for organic electronic materials, including ligands for metal-organic frameworks (MOFs) and emissive layers.
• Chemical Biology & Probe Synthesis: Useful for labeling and modifying biomolecules or creating molecular probes for diagnostic applications.
• Scale-up & Process Chemistry: The pinacol ester group offers improved stability for handling and storage during large-scale manufacturing processes.

Basic Information

Product Name	1,3-Dihydroisobenzofuran-5-Boronic Acid Pinacol Ester
CAS No.	1352037-60-5
Molecular Formula	C14H19BO3
Molecular Weight	246.11 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1-benzofuran; 1,3-Dihydroisobenzofuran-5-boronic acid pinacol ester; 5-(Pinacolatoboryl)-2,3-dihydro-1-benzofuran; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-dihydro-2-benzofuran; 2,3-Dihydrobenzofuran-5-boronic acid pinacol ester; 5-Borono-2,3-dihydrobenzofuran pinacol ester; CAS 1352037-60-5
EINECS	Contact for details

Quality Control

Our 1,3-Dihydroisobenzofuran-5-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development. Each lot is analyzed using advanced techniques including NMR, HPLC, and GC to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.