Description

2,4-Difluoro-3-Methylphenylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient and precise construction of complex molecular architectures. It is primarily required by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially fluorinated compounds with enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoro-methylphenyl moiety can contribute to improved activity and environmental profile.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for catalysis and as a building block for functional materials like OLEDs and organic semiconductors.
• Chemical Research & Development: Serves as a versatile reagent in academic and industrial labs for exploring new synthetic pathways and creating compound libraries for screening.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of complex, high-value target molecules under cGMP conditions where applicable.

Basic Information

Product Name	2,4-Difluoro-3-Methylphenylboronic Acid Pinacol Ester
CAS No.	1351985-05-1
Molecular Formula	C₁₃H₁₇BF₂O₂
Molecular Weight	254.08 g/mol
Synonyms	2,4-Difluoro-3-methylbenzeneboronic acid pinacol ester; (2,4-Difluoro-3-methylphenyl)boronic acid pinacol ester; 2-(2,4-Difluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Methyl-2,4-difluorophenylboronic acid pinacol ester; Pinacol (2,4-difluoro-3-methylphenyl)boronate; Boronic acid, B-(2,4-difluoro-3-methylphenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-3-Methylphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability for your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Typical 98-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.