Description

(R)-1-(1-Bromoethyl)-3,5-Bis(Trifluoromethyl)Benzene is a high-value, chiral building block of significant interest in advanced organic synthesis. Its core value lies in the combination of a reactive benzylic bromide handle with electron-withdrawing trifluoromethyl groups, enabling precise stereochemical control in complex molecule construction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly where the introduction of a chiral center and fluorinated aromatic systems is required.

Application

• Pharmaceutical Intermediate: Key chiral precursor for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of CNS drugs, antiviral agents, and enzyme inhibitors.
• Agrochemical Synthesis: Used in creating advanced, fluorinated agrochemicals such as herbicides, fungicides, and insecticides, where the trifluoromethyl groups enhance bioavailability and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Building block for novel fluorinated polymers, liquid crystals, and organic electronic materials with unique properties.
• Cross-Coupling Reactions: The benzylic bromide moiety makes it a suitable substrate for various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form new C-C bonds.
• Stereochemical Studies: Used as a model compound in methodological development for stereoselective synthesis and chiral analysis.

Basic Information

Item	Details
Product Name	(R)-1-(1-Bromoethyl)-3,5-Bis(Trifluoromethyl)Benzene
CAS No.	1351520-15-4
Molecular Formula	C11H7BrF6
Molecular Weight	333.07 g/mol
Synonyms	(R)-1-(1-Bromoethyl)-3,5-bis(trifluoromethyl)benzene; (R)-1-Bromo-1-(3,5-bis(trifluoromethyl)phenyl)ethane; (R)-α-Bromo-3,5-bis(trifluoromethyl)ethylbenzene; (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethyl bromide; (R)-1-Bromo-1-(3,5-di(trifluoromethyl)phenyl)ethane; (R)-1-(1-Bromoethyl)-3,5-di(trifluoromethyl)benzene; (R)-3,5-Bis(trifluoromethyl)-α-bromoethylbenzene; (R)-Enantiomer of 1-(1-Bromoethyl)-3,5-bis(trifluoromethyl)benzene
EINECS	Contact for details

Quality Control

Our (R)-1-(1-Bromoethyl)-3,5-Bis(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and enantiomeric purity, meeting the stringent requirements for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is sensitive to light and should be handled under an inert atmosphere when appropriate to maintain stability. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.