Description

1-(4-Bromo-2-Methylphenyl)-2,2,2-Trifluoroethanone is a high-purity trifluoromethyl ketone derivative, a crucial building block in modern organic synthesis. Its value lies in its unique molecular structure, which combines a bromo-methylphenyl group with a reactive trifluoroacetyl moiety, enabling precise chemical transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially those requiring trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides, fungicides, and pesticides, where the bromine atom allows for further functionalization.
• Material Science Research: Used in the synthesis of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing trifluoromethyl ketone group.
• Cross-Coupling Reactions: The aryl bromide functionality makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Heck couplings.
• Fluorine Chemistry: An important reagent for introducing the trifluoroacetyl group into complex molecules, a common motif in medicinal chemistry.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	1-(4-Bromo-2-Methylphenyl)-2,2,2-Trifluoroethanone
CAS No.	1351479-07-6
Molecular Formula	C9H6BrF3O
Molecular Weight	267.05 g/mol
Synonyms	4'-Bromo-2'-methyl-2,2,2-trifluoroacetophenone; 2,2,2-Trifluoro-1-(4-bromo-2-methylphenyl)ethanone; 1-(4-Bromo-o-tolyl)-2,2,2-trifluoroethanone; 4-Bromo-2-methyl-α,α,α-trifluoroacetophenone; α,α,α-Trifluoro-4'-bromo-2'-methylacetophenone; TFAP-Br-Me derivative; (4-Bromo-2-methylphenyl)(trifluoromethyl)methanone
EINECS	Contact for details

Quality Control

Every batch of 1-(4-Bromo-2-Methylphenyl)-2,2,2-Trifluoroethanone is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency meet the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specification results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.