Description

n-(4-Methoxyphenyl)-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. Its value lies in the protected boronic ester functional group, which is crucial for modern cross-coupling reactions like the Suzuki-Miyaura reaction, enabling efficient carbon-carbon bond formation. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries who are synthesizing complex molecules for new drug candidates, crop protection agents, or functional organic materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical coupling partner for constructing biaryl and heterobiaryl structures, a fundamental transformation in medicinal chemistry.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require complex pyridine-based architectures.
• Material Science & OLED Development: Acts as a precursor for creating organic semiconductors, light-emitting diodes (OLEDs), and other electronic materials due to its conjugated system.
• Chemical Biology & Probe Synthesis: Utilized for labeling and modifying biomolecules or creating molecular probes for diagnostic and research applications.
• Academic & Contract Research: A valuable reagent for synthetic methodology development and custom synthesis projects in university and CRO laboratories.

Basic Information

Item	Details
Product Name	n-(4-Methoxyphenyl)-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine
CAS No.	1351381-25-3
Molecular Formula	C19H25BN2O3
Molecular Weight	340.23 g/mol
Synonyms	4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-methoxyphenyl)pyridin-2-amine; 2-Amino-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-methoxyphenyl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-N-(4-methoxyphenyl)pyridin-2-amine; N-(4-Methoxyphenyl)-4-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine; Pinacol ester of [2-[(4-methoxyphenyl)amino]-4-methyl-5-pyridinyl]boronic acid; Boronic acid, B-[2-[(4-methoxyphenyl)amino]-4-methyl-5-pyridinyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our n-(4-Methoxyphenyl)-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.