Description

N,n-Dimethyl-3-((4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Oxy)Propan-1-Amine is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling key carbon-carbon bond-forming reactions, such as the Suzuki-Miyaura cross-coupling, which are fundamental in modern medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules, particularly for oncology and central nervous system (CNS) drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those requiring boronic acid/ester chemistry.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a crucial coupling partner for constructing biaryl and heterobiaryl structures prevalent in many modern therapeutics.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening and lead optimization phases to create diverse compound libraries.
• API Development: Integral to the research and process development of new Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Employed in the development of molecular probes for studying biological pathways and target validation.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents and herbicides.
• Material Science: Can be used in the synthesis of organic electronic materials and ligands for catalysis.

Basic Information

Product Name	N,n-Dimethyl-3-((4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Oxy)Propan-1-Amine
CAS No.	1351380-84-1
Molecular Formula	C17H29BN2O3
Molecular Weight	320.24 g/mol
Synonyms	2-((3-(Dimethylamino)propoxy)-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-((3-(dimethylamino)propoxy)-4-methylpyridine; N,N-Dimethyl-3-((4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)oxy)propan-1-amine; 1351380-84-1; Pinacol ester of (2-((3-(dimethylamino)propoxy)-4-methylpyridin-5-yl)boronic acid; Boronic ester intermediate CAS 1351380-84-1
EINECS	Contact for details

Quality Control

Our N,n-Dimethyl-3-((4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Oxy)Propan-1-Amine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with client specifications and supporting regulatory filings for drug development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.