Description

n-Benzyl-n-Ethyl-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is a high-value, organoboron building block essential for modern synthetic chemistry, particularly in pharmaceutical research and development. Its core value lies in the boronic ester functional group, which enables efficient Suzuki-Miyaura cross-coupling reactions for constructing complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries seeking to create novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for drug discovery programs, particularly for kinase inhibitors and other small molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for forming carbon-carbon bonds between the pyridine ring and various aryl or heteroaryl halides.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the pyridine-boronate scaffold imparts specific biological activity.
• Ligand Synthesis: Employed in the preparation of specialized nitrogen-containing ligands for catalysis and coordination chemistry.
• Material Science: A building block for creating organic electronic materials, such as those used in OLEDs or organic semiconductors, due to its conjugated system and functional handle.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	n-Benzyl-n-Ethyl-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine
CAS No.	1351206-48-8
Molecular Formula	C21H29BN2O2
Molecular Weight	352.28 g/mol
Synonyms	2-[(Benzyl(ethyl)amino]-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; N-Benzyl-N-ethyl-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-benzyl-N-ethyl-4-methylpyridin-2-amine; 1351206-48-8; BRN 14805813; AKOS040759246; ZB1049; CS-0417355
EINECS	Contact for details

Quality Control

Our n-Benzyl-n-Ethyl-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical coupling reactions. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with internal quality standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.