Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethoxy)Phenol is a high-value boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially those containing trifluoromethoxy and phenolic motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific aryl-boronate coupling partners.
• Material Science: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: An indispensable reagent in medicinal chemistry and process chemistry for constructing complex molecular architectures via cross-coupling.
• Ligand & Catalyst Development: Used to synthesize novel bidentate or polydentate ligands for catalytic systems.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethoxy)Phenol
CAS No.	1350989-48-8
Molecular Formula	C13H16BF3O4
Molecular Weight	304.07 g/mol
Synonyms	2-(Trifluoromethoxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethoxy)phenol; 2-(Trifluoromethoxy)phenylboronic acid pinacol ester; Phenol, 2-(trifluoromethoxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 2-Trifluoromethoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol; 4-Borono-2-(trifluoromethoxy)phenol pinacol ester
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethoxy)Phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.