Description

n-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine is a high-value boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone method for constructing complex carbon-carbon bonds. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) for drug discovery and development programs.
• Agrochemical Synthesis: Used to construct complex molecular scaffolds for novel herbicides, fungicides, and insecticides.
• Material Science Research: Building block for creating organic electronic materials, such as those used in OLEDs and semiconductors.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronate ester coupling partner for introducing the cyclopropylaminopyridine moiety into target molecules.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies and the exploration of new chemical entities in lead optimization.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services.

Basic Information

Item	Detail
Product Name	n-Cyclopropyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine
CAS No.	1350918-92-1
Molecular Formula	C14H21BN2O2
Molecular Weight	260.14 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-cyclopropylpyridin-2-amine; 2-Amino-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-cyclopropylpyridine; N-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine; 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-cyclopropyl-2-pyridinamine; Boronic acid, B-[2-(cyclopropylamino)-4-pyridinyl]-, 1,1-dimethylethyl ester; CAS 1350918-92-1
EINECS	Contact for details

Quality Control

Our n-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance in critical coupling reactions. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.