Description

4-Chloro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzenamine is a high-value, protected aniline derivative featuring a pinacol boronate ester group, making it a crucial building block in modern synthetic chemistry. This compound matters because it enables precise carbon-carbon and carbon-heteroatom bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in creating novel aryl-amine scaffolds for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific chlorinated aniline motifs.
• Material Science & OLED Development: Serves as a precursor for constructing conjugated organic molecules used in organic light-emitting diodes (OLEDs) and other electronic materials.
• Ligand & Catalyst Preparation: Employed in the synthesis of specialized ligands for transition metal catalysis and as a building block for functionalized catalysts.
• Chemical Biology & Probe Development: Utilized to create molecular probes and labeled compounds for studying biological pathways and diagnostic applications.
• Polymer Chemistry: Acts as a monomer or functionalization agent for creating specialty polymers with tailored electronic or mechanical properties.

Basic Information

Product Name	4-Chloro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzenamine
CAS No.	1350842-61-3
Molecular Formula	C12H17BClNO2
Molecular Weight	253.53 g/mol
Synonyms	2-(4-Amino-2-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 3-Amino-4-chlorophenylboronic acid pinacol ester; (4-Amino-2-chlorophenyl)boronic acid pinacol ester; 2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine; CAS 1350842-61-3; 4-Chloro-3-boronic acid pinacol ester aniline
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzenamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for critical cross-coupling applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use to maintain stability. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.