Description

n-Cyclopropyl-N,3-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is a high-value, functionalized pyridine derivative containing a pinacol boronate ester group, making it a versatile building block for modern synthetic chemistry. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for forming carbon-carbon bonds in complex molecule assembly. It is an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable boronic acid derivatives for drug discovery and development pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in constructing novel fungicides, herbicides, and insecticides that require the incorporation of a substituted pyridine core for enhanced bioactivity.
• Material Science Research: Serves as a monomer or functional unit in the development of organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Medicinal Chemistry & Drug Discovery: Enables rapid parallel synthesis and library generation for structure-activity relationship (SAR) studies via efficient cross-coupling.
• Chemical Biology Probes: Utilized in the creation of tagged molecules or inhibitors for proteomics and target identification studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds at various scales.

Basic Information

Item	Detail
Product Name	n-Cyclopropyl-N,3-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine
CAS No.	1350637-54-5
Molecular Formula	C16H25BN2O2
Molecular Weight	288.20 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-cyclopropyl-N,3-dimethylpyridin-2-amine; 2-Amino-N-cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methylpyridine; N-Cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methylpyridin-2-amine; Boronic acid, B-[2-[(cyclopropylamino)methyl]-6-methyl-3-pyridinyl]-, pinacol ester; CAS 1350637-54-5; 1350637-54-5
EINECS	Contact for details

Quality Control

Our n-Cyclopropyl-N,3-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the stringent requirements for research and process chemistry. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability, consistency, and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation, as boronate esters can be sensitive to prolonged exposure to air and humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.