Description

5-Amino-2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is a high-value, multifunctional boronic ester derivative that serves as a critical building block in advanced organic synthesis. Its core value lies in the combination of an electron-donating amino group and a protected boronic acid moiety, enabling precise cross-coupling reactions and the construction of complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and materials science industries, particularly for creating novel active ingredients and functional organic materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to construct complex heterocyclic scaffolds found in modern pesticides and herbicides, contributing to improved efficacy and selectivity.
• Organic Light-Emitting Diodes (OLEDs): Serves as a building block for electron-transport materials and host molecules in display and lighting technologies.
• Ligand and Catalyst Development: The amino and nitrile groups allow for functionalization into novel chelating ligands for transition metal catalysis.
• Polymer and Material Science: Incorporated into specialty polymers to impart specific electronic or self-healing properties via dynamic covalent chemistry.
• Chemical Biology Probes: Utilized in the development of activity-based probes and sensors due to its reactive handles for bioconjugation.

Basic Information

Product Name	5-Amino-2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	1350635-52-7
Molecular Formula	C13H17BN2O2
Molecular Weight	244.10 g/mol
Synonyms	2-Amino-5-cyanophenylboronic acid pinacol ester; 5-Cyano-2-aminophenylboronic acid pinacol ester; (5-Cyano-2-aminophenyl)boronic acid pinacol ester; 2-Amino-5-cyanobenzene-1-boronic acid pinacol ester; 2-(5-Amino-2-cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Amino-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; Pinacol 5-amino-2-cyanophenylboronate
EINECS	Contact for details

Quality Control

Our 5-Amino-2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.