Description

4-Methyl-2-(2-(Piperidin-4-Yl)Ethoxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a sophisticated boronic ester derivative and a key synthetic intermediate in modern pharmaceutical research. This compound matters for its role as a crucial building block in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. Pharmaceutical R&D and fine chemical synthesis teams need this high-purity intermediate to accelerate the discovery and development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic programs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for palladium-catalyzed carbon-carbon bond formation, essential for creating complex biaryl and heterobiaryl scaffolds.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Chemical Biology Probes: Enables the synthesis of tagged molecules for studying biological pathways and target engagement.
• Process Chemistry Development: Employed in the scale-up and route scouting for the commercial manufacturing of advanced pharmaceutical intermediates.
• Academic Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies and catalytic systems.

Basic Information

Product Name	4-Methyl-2-(2-(Piperidin-4-Yl)Ethoxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1350559-18-0
Molecular Formula	C20H31BN2O3
Molecular Weight	358.29 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[2-(4-piperidinyl)ethoxy]-4-methylpyridine; 4-Methyl-2-[2-(piperidin-4-yl)ethoxy]pyridine-5-boronic acid pinacol ester; 2-(2-(Piperidin-4-yl)ethoxy)-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; PINACOL 4-METHYL-2-(2-(PIPERIDIN-4-YL)ETHOXY)PYRIDIN-5-YLBORONATE; CAS 1350559-18-0
EINECS	Contact for details

Quality Control

Our 4-Methyl-2-(2-(Piperidin-4-Yl)Ethoxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and identity confirmation suitable for sensitive coupling reactions. Certificates of Analysis (COA) with full analytical data are provided to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.