Description

2-(3-Fluoro-4-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical advanced intermediate in modern synthetic organic chemistry. Its primary value lies in enabling efficient, selective carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-quality building blocks for drug discovery, active ingredient synthesis, and functional material development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing a fluorinated biaryl scaffold.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and semiconductors.
• Cross-Coupling Reactions: Specifically designed for use in palladium-catalyzed Suzuki-Miyaura cross-coupling to form biaryl and heterobiaryl linkages with high efficiency.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and labeled compounds for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic routes.

Basic Information

Product Name	2-(3-Fluoro-4-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1350426-06-0
Molecular Formula	C15H22BFO3
Molecular Weight	280.14 g/mol
Synonyms	3-Fluoro-4-isopropoxyphenylboronic acid pinacol ester; (3-Fluoro-4-isopropoxyphenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[3-fluoro-4-(propan-2-yloxy)phenyl]-1,3,2-dioxaborolane; 2-(3-Fluoro-4-isopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (3-Fluoro-4-isopropoxyphenyl)boronate; 3-Fluoro-4-isopropoxybenzeneboronic acid pinacol ester; CAS 1350426-06-0
EINECS	Contact for details

Quality Control

Every batch of our 2-(3-Fluoro-4-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our standard quality protocol includes comprehensive analysis by NMR (¹H, ¹³C, ¹⁹F), HPLC, and GC to confirm identity and purity. A detailed Certificate of Analysis (COA) documenting all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged use or when opening a new container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.