Description

3-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine is a high-purity, protected aniline derivative featuring a pinacol boronate ester functional group, making it a versatile and critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, catalyst development, and the synthesis of functional organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing biphenyl or aryl amine motifs for oncology, CNS, and antiviral therapies.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the introduction of a specific methoxy-aminophenyl moiety is required.
• Material Science & OLED Development: Serves as a building block for creating organic semiconductors, charge-transport materials, and emissive layers in organic light-emitting diodes (OLEDs) and other electronic devices.
• Ligand & Catalyst Preparation: Employed in the synthesis of sophisticated ligands for transition metal catalysis and as a scaffold for functionalized catalysts.
• Chemical Biology & Proteomics: Useful for bioconjugation and labeling strategies, acting as a handle for introducing boron-based functionalities into biomolecules.
• Polymer Chemistry: Incorporated as a monomer or functionalization agent in the production of specialty polymers with tailored properties.

Basic Information

Product Name	3-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzenamine
CAS No.	1350377-66-0
Molecular Formula	C13H20BNO3
Molecular Weight	249.12 g/mol
Synonyms	4-Amino-2-methoxyphenylboronic acid pinacol ester; 2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methoxyaniline; 3-Methoxy-4-(pinacolatoboryl)aniline; 2-Methoxy-4-aminophenylboronic acid pinacol ester; 4-Amino-2-methoxybenzeneboronic acid pinacol ester; AN-016/40138035; BRN 17155697
EINECS	Contact for details

Quality Control

Our 3-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliable consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.