Description

[3,5-Difluoro-4-(Oxetan-3-Yloxy)Phenyl]Methanamine is a high-purity, advanced pharmaceutical intermediate featuring a unique oxetane ether linkage. This compound matters as a critical building block for medicinal chemists, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and pharmacokinetic properties. It is primarily needed by R&D and production teams in the pharmaceutical and biotechnology industries for developing next-generation therapeutics, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates, especially those targeting kinase inhibition.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component connecting E3 ligase ligands to target protein binders.
• CNS Drug Discovery: Used to create novel compounds designed to cross the blood-brain barrier, facilitated by its structural motifs.
• Oncology Research: Integral for constructing small molecule inhibitors for various cancer-related protein targets.
• Chemical Biology Probes: Employed in the design of tool compounds for target validation and pathway elucidation studies.
• Agrochemical Research: Potential use as an intermediate in the development of new crop protection agents with improved efficacy.

Basic Information

Product Name	[3,5-Difluoro-4-(Oxetan-3-Yloxy)Phenyl]Methanamine
CAS No.	1349719-21-6
Molecular Formula	C10H11F2NO2
Molecular Weight	215.20 g/mol
Synonyms	4-(Aminomethyl)-2,6-difluorophenyl oxetan-3-yl ether; 1-[3,5-Difluoro-4-(oxetan-3-yloxy)phenyl]methanamine; 3,5-Difluoro-4-(3-oxetanyloxy)benzenemethanamine; (3,5-Difluoro-4-(oxetan-3-yloxy)phenyl)methanamine; 4-(Oxetan-3-yloxy)-3,5-difluorobenzylamine; 3,5-Difluoro-4-(oxetan-3-yloxy)benzylamine; Benzenemethanamine, 3,5-difluoro-4-(3-oxetanyloxy)-
EINECS	Contact for details

Quality Control

Our [3,5-Difluoro-4-(Oxetan-3-Yloxy)Phenyl]Methanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.