Description

1-(6-Fluoroquinolin-8-Yl)Ethanone is a high-purity fluorinated quinoline derivative, serving as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. Its core value lies in enabling the development of novel active compounds, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine atoms is a key strategy for modulating biological activity and metabolic stability. This compound is essential for research chemists and process development scientists in pharmaceutical R&D, fine chemical synthesis, and material science applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in the development of fluorinated quinolone antibiotics and other therapeutic agents.
• Agrochemical Research: Used as a building block for creating new pesticides and herbicides, where the fluorinated quinoline structure can enhance efficacy and environmental profile.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, cyclizations, and other transformations to construct complex heterocyclic systems for various research purposes.
• Material Science: Investigated for the development of organic electronic materials, such as OLEDs or sensors, due to its conjugated quinoline core.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	1-(6-Fluoroquinolin-8-Yl)Ethanone
CAS No.	1346817-49-9
Molecular Formula	C11H8FNO
Molecular Weight	189.19 g/mol
Synonyms	8-Acetyl-6-fluoroquinoline; 6-Fluoro-8-acetylquinoline; 1-(6-Fluoro-8-quinolyl)ethanone; Ethanone, 1-(6-fluoro-8-quinolinyl)-; 6-Fluoroquinoline-8-carbaldehyde (common misnomer, corrects to acetyl); 1-(6-Fluoroquinolin-8-yl)ethan-1-one
EINECS	Contact for details

Quality Control

Our 1-(6-Fluoroquinolin-8-Yl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.