Description

2-(Ethylamino)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinonitrile is a high-value, functionalized pyridine derivative containing a pinacol boronate ester group, making it a crucial intermediate in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone method for constructing complex carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients, and in materials science for creating advanced organic electronic components.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the discovery and synthesis of new herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science Precursor: Serves as a monomer or functional unit in the synthesis of organic semiconductors, ligands for catalysts, and advanced polymers.
• Chemical Biology Probe Development: Employed to create tagged molecules for studying biological pathways and protein interactions.
• Cross-Coupling Reactions: Specifically designed as a versatile boronic ester partner in Suzuki-Miyaura couplings to introduce the nicotinonitrile scaffold into complex molecular architectures.
• Library Synthesis for Drug Discovery: Enables high-throughput parallel synthesis to generate diverse compound libraries for screening against biological targets.

Basic Information

Product Name	2-(Ethylamino)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinonitrile
CAS No.	1346809-52-6
Molecular Formula	C16H24BN3O2
Molecular Weight	301.20 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(ethylamino)nicotinonitrile; 2-Ethylamino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile; 2-(Ethylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinecarbonitrile; N-Ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyanopyridin-2-amine; Pinacol [2-(ethylamino)-5-cyano-3-pyridyl]boronate
EINECS	Contact for details

Quality Control

Our 2-(Ethylamino)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and easily oxidized nature. Allow the container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.