Description

2-(Dimethylamino)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinonitrile is a high-value, multi-functional boronic ester derivative of a substituted nicotinonitrile, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, to construct complex heterocyclic scaffolds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Building block for creating novel herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science: Used in the development of organic electronic materials, such as OLEDs and organic semiconductors, due to its electron-deficient pyridine core.
• Chemical Synthesis: Versatile reagent for Suzuki-Miyaura cross-coupling reactions to form biaryl and heterobiaryl structures central to many functional molecules.
• Ligand & Catalyst Development: Serves as a precursor for creating novel bidentate ligands used in homogeneous catalysis.
• Life Science Probes: Utilized in the design and synthesis of fluorescent probes and bio-conjugation agents for diagnostic applications.

Basic Information

Product Name	2-(Dimethylamino)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinonitrile
CAS No.	1346809-50-4
Molecular Formula	C14H20BN3O2
Molecular Weight	273.14 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(dimethylamino)nicotinonitrile; 2-Dimethylamino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyanopyridine; 2-(Dimethylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile; 3-Cyano-2-(dimethylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; PINACOL 2-(DIMETHYLAMINO)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)NICOTINONITRILE
EINECS	Contact for details

Quality Control

Our 2-(Dimethylamino)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for critical synthetic applications. Certificates of Analysis (COA) with full characterization data are provided to guarantee traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.