Description

tert-Butyl 4-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)pyridin-3-yl)piperazine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core and a protected boronic ester functional group. This compound is critical for enabling efficient cross-coupling reactions, particularly in the synthesis of complex small molecule drug candidates. It is primarily utilized by research and development organizations and contract manufacturing organizations (CMOs) in the pharmaceutical and agrochemical sectors for constructing novel chemical entities.

Application

• Suzuki-Miyaura Cross-Coupling Reagent: A key building block for forming carbon-carbon bonds in medicinal chemistry, enabling the introduction of the pyridinylpiperazine moiety into target molecules.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic architectures.
• Chemical Biology Probe Development: Employed in the synthesis of tool compounds and probes for target identification and validation in biological systems.
• Material Science Research: Potential use as a monomer or functional unit in the synthesis of organic electronic materials or metal-organic frameworks (MOFs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and scale-up projects under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl 4-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)pyridin-3-yl)piperazine-1-carboxylate
CAS No.	1346808-98-7
Molecular Formula	C20H32BN3O4
Molecular Weight	389.30 g/mol
Synonyms	1-Boc-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)piperazine; tert-Butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridyl]piperazine-1-carboxylate; 3-Piperazinyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-1-carboxylic acid tert-butyl ester; 1-Boc-4-(5-(pinacolboryl)pyridin-3-yl)piperazine; 5-(1-Boc-piperazin-4-yl)-3-pyridineboronic acid pinacol ester; 3-(1-Boc-piperazin-4-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)pyridin-3-yl)piperazine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment supports applications from research to pre-clinical development under appropriate quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the certificate of analysis. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.