Description

3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoxazole is a high-value, organoboron building block essential for modern synthetic chemistry. This compound matters as a versatile reagent for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. Pharmaceutical, agrochemical, and advanced material researchers need it for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where the isoxazole moiety is a common bioactive component.
• Material Science: Serves as a precursor for creating organic electronic materials, such as OLEDs and semiconductors, via cross-coupling polymerization.
• Chemical Biology: Employed in the synthesis of probes and ligands for studying biological systems and enzyme inhibition.
• Academic & Contract Research: A critical reagent in university and CRO laboratories for methodology development and complex molecule synthesis.
• Scale-up Process Chemistry: Suitable for use in pilot plant and manufacturing-scale Suzuki coupling reactions due to its stability and reactivity.

Basic Information

Product Name	3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoxazole
CAS No.	1346808-44-3
Molecular Formula	C₁₀H₁₆BNO₃
Molecular Weight	209.05 g/mol
Synonyms	3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxazole; 3-Methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methylisoxazole; 3-Methyl-5-(pinacolatoboryl)isoxazole; 3-Methylisoxazole-5-boronic acid pinacol ester; Isoxazole-5-boronic acid, 3-methyl-, pinacol ester; 1346808-44-3; 3-Methyl-5-(pinacolboron)isoxazole
EINECS	Contact for details

Quality Control

Our 3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoxazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.