Description

5-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its primary value lies in its role as a versatile intermediate in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality reagents for Suzuki-Miyaura and other palladium-catalyzed couplings.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing the isoxazole heterocycle.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require the incorporation of the isoxazole-boronate moiety.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as OLEDs and organic semiconductors, where precise molecular structure is crucial.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and bioconjugates for studying biological processes and target identification.
• Academic & Industrial R&D: A fundamental reagent for methodology development in organic synthesis and for creating bespoke chemical libraries for screening.

Basic Information

Product Name	5-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoxazole
CAS No.	1346808-41-0
Molecular Formula	C₁₀H₁₆BNO₃
Molecular Weight	209.05 g/mol
Synonyms	5-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-methylisoxazole; 5-Methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole; Pinacol 5-Methylisoxazole-4-boronate; 5-Methylisoxazole-4-boronic acid pinacol ester; 5-Methyl-4-(pinacolatoboryl)isoxazole; 4-Borono-5-methylisoxazole pinacol ester
EINECS	Contact for details

Quality Control

Our 5-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.