Description

5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,4-Thiadiazole is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-quality intermediates for drug discovery and advanced material development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing the 1,2,4-thiadiazole heterocycle, which is associated with diverse biological activities.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the Suzuki coupling to create complex molecular architectures.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and organic semiconductors.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and bioconjugates for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Academic & Industrial R&D: A staple reagent in chemistry laboratories for methodological development and the exploration of new chemical spaces in medicinal and synthetic chemistry.

Basic Information

Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,4-Thiadiazole
CAS No.	1346808-34-1
Molecular Formula	C8H15BN2O2S
Molecular Weight	214.09 g/mol
Synonyms	1,2,4-Thiadiazole-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,4-thiadiazole; 1,2,4-Thiadiazol-5-ylboronic acid pinacol ester; 5-(Pinacolatoboryl)-1,2,4-thiadiazole; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,4-thiadiazole; 1,2,4-Thiadiazole-5-boronic acid, pinacol ester; 5-Borono-1,2,4-thiadiazole pinacol ester
EINECS	Contact for details

Quality Control

Our 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,4-Thiadiazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient humidity. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.