Description

2-(Cyclobutylmethoxy)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value, advanced pharmaceutical intermediate featuring a pyridine core functionalized with a cyclobutylmethoxy group and a pinacol boronate ester. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient Suzuki-Miyaura cross-coupling reactions to construct complex biaryl structures. It is primarily needed by R&D scientists and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and drug candidates. The CAS number for this compound is 1346708-00-6.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for oncology, CNS, and antiviral therapies.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for constructing C-C bonds to create novel biaryl and heterobiaryl scaffolds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Employed in the research of organic electronic materials, such as ligands for OLEDs and organic semiconductors.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized as a linker or functional component in the design of targeted protein degraders.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke molecules for client R&D programs.

Basic Information

Product Name	2-(Cyclobutylmethoxy)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1346708-00-6
Molecular Formula	C16H24BNO3
Molecular Weight	289.18 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(cyclobutylmethoxy)pyridine; 2-(Cyclobutylmethoxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-Pinacolatoboryl-2-(cyclobutylmethoxy)pyridine; 2-Cyclobutylmethoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine; Pyridine, 2-(cyclobutylmethoxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; CAS 1346708-00-6
EINECS	Contact for details

Quality Control

Every batch of 2-(Cyclobutylmethoxy)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including NMR, HPLC, and GC, to ensure high purity and consistency suitable for advanced R&D and scale-up processes. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.