Description

2-Isobutoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. This compound is valued for its role in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for forming carbon-carbon bonds. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science sectors who require reliable, high-quality boronic ester reagents for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific pyridine-based architectures.
• Material Science: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Chemical Research: A critical reagent in academic and industrial R&D for palladium-catalyzed cross-coupling reactions to construct biaryl and heterobiaryl systems.
• Ligand Synthesis: Used to prepare sophisticated ligands for catalysis and metal-organic frameworks (MOFs).
• Process Chemistry: Employed in scale-up and route development for the commercial manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-Isobutoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1346707-87-6
Molecular Formula	C15H24BNO3
Molecular Weight	277.17 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-isobutoxypyridine; 2-Isobutoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Pinacol 2-Isobutoxy-4-pyridinylboronate; 2-(2-Isobutoxypyridin-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(2-Isobutoxy)-pyridine boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Isobutoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.