Description

2-(Acetoxymethyl)-3-(7,7-Dimethyl-1-Oxo-3,4,7,8-Tetrahydro-1H-Cyclopenta[4,5]Pyrrolo[1,2-A]Pyrazin-2(6H)-Yl)Phenylboronic Acid Pinacol Ester is a sophisticated boronic ester derivative designed for advanced synthetic applications. This compound is a critical high-purity building block in modern pharmaceutical research and development, enabling precise chemical transformations. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly in oncology and targeted therapy research.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile organoboron reagent for constructing biaryl and heterobiaryl structures central to medicinal chemistry.
• Proteolysis-Targeting Chimera (PROTAC) Development: Used in the construction of linker-warhead components for targeted protein degradation platforms.
• Chemical Biology Probe Synthesis: Enables the creation of labeled molecules for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Academic Research: Employed in university and institutional labs for methodological development in synthetic organic chemistry.

Basic Information

Product Name	2-(Acetoxymethyl)-3-(7,7-Dimethyl-1-Oxo-3,4,7,8-Tetrahydro-1H-Cyclopenta[4,5]Pyrrolo[1,2-A]Pyrazin-2(6H)-Yl)Phenylboronic Acid Pinacol Ester
CAS No.	1346676-30-9
Molecular Formula	C28H35BN2O5
Molecular Weight	490.41 g/mol
Synonyms	2-(Acetoxymethyl)-3-(7,7-dimethyl-1-oxo-3,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2(6H)-yl)phenylboronic acid pinacol ester; 2-(Acetoxymethyl)-3-(7,7-dimethyl-1-oxo-3,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2(6H)-yl)benzeneboronic acid pinacol ester; Boronic acid, B-[2-(acetoxymethyl)-3-(7,7-dimethyl-1-oxo-3,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2(6H)-yl)phenyl]-, pinacol ester; CAS 1346676-30-9; (2-(Acetoxymethyl)-3-(7,7-dimethyl-1-oxo-3,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2(6H)-yl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (NMR)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.