Description

Ethyl 2,2-Difluoro-3-(Methylamino)Propanoate is a specialized fluorinated amino acid ester building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the difluoro and methylamino functional groups, enabling the construction of complex molecules with tailored properties. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, particularly protease inhibitors and other biologically active molecules.
• Agrochemical Research: Used in the synthesis of novel herbicides and pesticides where the fluorine atoms enhance metabolic stability and bioavailability.
• Peptidomimetics: Serves as a non-natural, fluorinated amino acid analog in the design of peptide-like compounds with improved pharmacological profiles.
• Material Science Precursor: Potential building block for specialty polymers and coatings that require specific fluorine-containing motifs.
• Chemical Biology Probes: Useful for incorporating fluorine tags into molecules for studies using techniques like 19F NMR spectroscopy.

Basic Information

Item	Details
Product Name	Ethyl 2,2-Difluoro-3-(Methylamino)Propanoate
CAS No.	1346597-51-0
Molecular Formula	C6H11F2NO2
Molecular Weight	167.16 g/mol
Synonyms	Ethyl 2,2-Difluoro-3-(methylamino)propionate; 3-(Methylamino)-2,2-difluoropropanoic Acid Ethyl Ester; 2,2-Difluoro-3-(methylamino)propionic Acid Ethyl Ester; Ethyl 3-(Methylamino)-2,2-difluoropropanoate; Methylamino-difluoropropanoate Ethyl Ester; DFMAE Ester; CAS 1346597-51-0
EINECS	Contact for details

Quality Control

Our Ethyl 2,2-Difluoro-3-(Methylamino)Propanoate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) and highly volatile nature, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.