Description

Ethyl 3-[Benzyl(Methyl)Amino]-2,2-Difluoropropanoate is a high-value, fluorinated amino acid ester building block designed for advanced synthetic chemistry. This compound matters for its role as a key intermediate in the development of novel pharmaceuticals and agrochemicals, where the difluoromethyl group can significantly alter biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting protease inhibitors and other enzyme modulators.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance lipophilicity and biological uptake.
• Peptidomimetics Synthesis: Serves as a non-natural amino acid analog for creating peptide mimics with improved stability against enzymatic degradation.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis or as a precursor for novel organocatalysts.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Material Science Precursor: Acts as a monomer or functionalization agent for specialty polymers with unique surface properties.

Basic Information

Product Name	Ethyl 3-[Benzyl(Methyl)Amino]-2,2-Difluoropropanoate
CAS No.	1346597-47-4
Molecular Formula	C13H17F2NO2
Molecular Weight	257.28 g/mol
Synonyms	Ethyl 3-(Benzylmethylamino)-2,2-difluoropropanoate; 2,2-Difluoro-3-(N-methyl-N-benzylamino)propionic Acid Ethyl Ester; 3-[Benzyl(Methyl)Amino]-2,2-Difluoropropanoic Acid Ethyl Ester; N-Benzyl-N-methyl-2,2-difluoro-3-ethoxy-3-oxopropylamine; Ethyl N-Benzyl-N-methyl-2,2-difluoro-3-aminopropanoate; 1346597-47-4; BAFF Ethyl Ester (context-specific abbreviation).
EINECS	Contact for details

Quality Control

Our Ethyl 3-[Benzyl(Methyl)Amino]-2,2-Difluoropropanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistent batch-to-batch reproducibility. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.