Description

1-[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenyl]-Cyclopropanecarbonitrile is a high-value boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone technology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, scalable methods for carbon-carbon bond formation.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting CNS disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Building block for organic light-emitting diodes (OLEDs), liquid crystals, and conductive polymers.
• Chemical Research & Development: Enables the exploration of new chemical space in medicinal chemistry and catalyst design.
• Scale-Up Process Chemistry: Suitable for transitioning from laboratory-scale discovery to pilot and commercial manufacturing.

Basic Information

Product Name	1-[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenyl]-Cyclopropanecarbonitrile
CAS No.	1346264-25-2
Molecular Formula	C16H20BNO2
Molecular Weight	269.15 g/mol
Synonyms	3-(1-Cyanocyclopropyl)phenylboronic acid pinacol ester; [3-(1-Cyanocyclopropyl)phenyl]boronic acid pinacol ester; 3-(Cyclopropanecarbonitrile-1-yl)phenylboronic acid pinacol ester; 1-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropanecarbonitrile; 3-(1-Cyano-1-cyclopropyl)phenylboronic acid pinacol ester; Boronic acid, B-[3-(1-cyanocyclopropyl)phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 1-[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenyl]-Cyclopropanecarbonitrile is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC, to ensure high purity and consistent performance for critical coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.